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Exploring the Intersection between Artificial Intelligence and Biological Sciences: Focus on Uses and Challenges

This report examines how artificial intelligence is transforming biosafety, biosecurity, biodefense, and global health, while simultaneously introducing new biological risks. Drawing on a systematic review of 169 scientific articles and surveys of life science professionals across Latin America, it finds that AI tools are increasingly applied to epidemiological prediction, protein design, and laboratory automation, yet […]

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Characterizing the Global Polycrisis: A Systematic Review of Recent Literature

The authors examine the concept of polycrisis, a term that has gained prominence for describing the interconnected nature of global challenges. Through a systematic review of 2,299 publications, the results indicate a common understanding of the polycrisis as multiple co-occurring, causally entangled crises with synergistic and cascading effects on multiple systems degrading humanity’s prospects. While

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A Systemic Risk Assessment Methodological Framework for the Global Polycrisis

The paper examines two historical global food–energy crises, highlighting the limitations of traditional risk management approaches in addressing today’s complex and interconnected global risks. The authors propose a methodological framework for assessing systemic risks in a global polycrisis context, which includes exploring system architectures, considering transformational responses away from risks, and applying cross-cutting practices. They

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The Impact of Polycrisis on Healthcare Systems—Analyzing Challenges and the Role of Social Epidemiology

This article examines how overlapping global crises are converging to form a polycrisis that places unprecedented strain on healthcare systems worldwide. Applying social epidemiology to the analysis of polycrisis, the authors highlight how these interconnected threats amplify one another, exposing systemic vulnerabilities and deepening health inequities. Drawing on data from missed hospitalizations, conflict zones such

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Dimensional characterization and Pathway Modeling for Catastrophic AI Risks

This paper examines catastrophic AI risks using a framework that combines seven risk dimensions: intent, competency, entity, polarity, linearity, reach, and order, along with risk pathway modelling to link hazards to harms. It analyzes six major risk types: Chemical, Biological, Radiological, and Nuclear (CBRN); cyber offence; sudden and gradual loss of control; environmental; and geopolitical.

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Echoes of Uncertainty: Reimagining Complexity of Global Risks in the Shadow of the Russian–Ukrainian Conflict

The authors explore risk perceptions in Ukraine and Poland in the context of the ongoing Russian–Ukrainian conflict. Drawing on cross-sectional survey data, the research reveals significant differences in how respondents from both countries perceive a range of global threats. By comparing perceptions of multiple potential risks that individuals may face in the foreseeable future, the

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Coping with Persistent Disruptive Stressors and Polycrisis: Community-Based Policy Making and Local Empowerment

The authors propose a conceptual framework for governing polycrisis and systemic risks through a bottom-up, community-based approach. They introduce the “risk governance triangle”, linking persistent disruptive stressors, risk-absorbing systems, and contextual modifiers, and structure these elements using the Pagoda model, which identifies five interrelated layers: natural conditions, institutional arrangements, technical and social infrastructure, the built

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Tipping Cascades Between Conflict and Cooperation in Climate Change

The authors examine the complex interplay between climate change and security, offering a systems-based modelling approach to understanding transitions between conflict and cooperation. Drawing on empirical research and the case study of Lake Chad, the article explores how climate risks act as conflict multipliers through tipping points, cascading effects, and multi-agent interactions. Using bi-stable tipping

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Towards a Theory of Coupled Sociopolitical Events-Planetary Boundaries, Crises, Policrisis and Earth System Syndromes

This paper introduces a novel modelling framework to evaluate how specific sociopolitical events influence the Earth System and their interaction with Planetary Boundaries. The authors present an interacting matrix model that links sociopolitical dynamics with biophysical thresholds, enabling the exploration of possible future trajectories, including scenarios that may trigger crises and polycrises. By modelling Planetary

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Global Food Security in a Turbulent World: Reviewing the Impacts of the Pandemic, the War and Climate Change

The authors explore how the COVID-19 pandemic, the Russia–Ukraine war, and climate change have jointly disrupted global food security. Drawing on recent empirical evidence, the paper examines the mechanisms through which each shock has affected the four key dimensions of food security: availability, access, utilization, and stability. By highlighting the compounding effects of these overlapping

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