Towards One Health Action for Addressing Antimicrobial Resistance in the Age of Polycrisis

The authors argue that antimicrobial resistance (AMR) represents a major One Health issue, driven by a range of accelerators, including emerging climate and social challenges. In the context of a worsening polycrisis, they call for an ecosystem-centered governance agenda based on four pillars: identifying local environmental drivers, mapping transmission pathways, reducing AMR stability and selection pressures, and establishing inclusive, cross-sectoral governance. Emphasizing wastewater, agriculture, and pollution, the article underscores the need for adaptive, precautionary, and coordinated action to address AMR as both a scientific and political challenge.